History of Vaccines: What This Means For Coronavirus


Today, Pfizer and BioNTech announced that they are submitting their Coronavirus vaccine to the Food and Drug Administration for Emergency Use Approval.

What are vaccines, when were they first developed, and what is the road to an approved vaccine in today’s world?

“Vaca” in the word vaccine sounds like “cow.” The word comes from the Latin phrase Variolae vaccine, meaning the “smallpox of the cow,” and referred to cowpox. What does vaccination have to do with cowpox?

Edward Jenner, in 1789 was working on a way to treat the deadly smallpox pandemic, a particularly deadly killer that had killed almost half a million Europeans during the 1700s and 1800s, and perhaps as many as 300-500 million people worldwide over its almost 500-year history. The story goes that when Jenner was a 13-year-old orphan boy and apprentice to a country surgeon, he’d overheard a beautiful milkmaid’s boast. She had a “peaches and cream” complexion that was flawless and bragged:

“I shall never have smallpox for I have had cowpox. I shall never have an ugly pockmarked face.”

Edward Jenner

Edward Jenner

Jenner, who became a British physician and scientist, tested his theory that exposure to cowpox would protect people from the deadlier smallpox by taking the pus from a cowpox pustule and vaccinating a young boy. After the boy proved immune, he further vaccinated several other children, including his 11-month-old-son. He successfully developed an effective vaccine against smallpox in this way, the first of its kind, and was aptly called “the father of immunology.”

Vaccines vs. Inoculations

At this time, smallpox inoculation was not new and was a standard practice, having come to England some 68 years earlier from Constantinople. Variolation, one popular form of the practice, had a serious downside. Variolation involved taking material from another person already infected with smallpox and transferring that to the patient in the hopes of producing a mild infection and an immune response.

Cotton Mather

Cotton Mather

This practice, originating in China years before, had passed through the Middle East before coming to England, Europe, and eventually America. George Washington ordered the Continental Army to be variolated. Early 18th-century Puritan pastors like Cotton Mather in Boston and Jonathan Edwards at Princeton popularized the practice. Edwards caught the disease but did not survive it. Edward’s daughter Ester and her husband Reverend Aaron Burr, Sr. also succumbed to smallpox.

The danger of variolation is that it makes the patient contagious with smallpox until they develop their own antibodies, possibly infecting others. Additionally, without standards of dosing or properly skilled physicians, it could kill the variolated patient. Ultimately the collateral smallpox cases caused by variolated patients immediately after inoculation eventually outweighed the benefits, and vaccination ultimately replaced it.

Smallpox vaccine

Smallpox vaccine

Vaccines’ Benefits

Vaccination had the benefit of not infecting others beyond the immediate subject because it was made from the weaker cowpox. Edward Jenner first used it in 1796. In 1967 a global effort of higher vaccine production and needle technology advancements led to the eventual elimination of smallpox in 1979, according to the World Health Organization (WHO.)

Louis Pasteur

Louis Pasteur

Louis Pasteur honored Jenner by broadening the term “vaccine” to refer to the artificial induction of immunity against any infectious disease. Pasteur and his successors created vaccines for Diphtheria, Measles, Mumps, Rubella, and Influenza.

Vaccines can be prophylactic in nature to prevent or ease the effects of a future infection. Alternatively, they can be therapeutic in nature, to fight a disease that has already occurred, such as rabies and tetanus.

Over the last two centuries, vaccines have been developed for Smallpox, Measles, Mumps, Rubella (MMR combined vaccine); Chickenpox, Shingles, Yellow fever, Typhoid, Hepatitis A and B, Rabies; Diphtheria, Tetanus (DTP combined vaccine); Pneumonia, blood infections, bacterial Meningitis, and some forms of Influenza.

There are many “flu” viruses, and the flu shot you may get each year addresses three or four of them for the upcoming flu season. But constant mutation requires a different vaccination each year.

Vaccines’ Development

Vaccines typically take 10-12 years to develop and sometimes as long as 20 years to perfect. A vaccine is rarely developed in less than five years. With a tip of the hat to Star Trek‘s faster-than-light travel, Operation Warp Speed is an American government program that has funded billions of dollars for medical research to develop and manufacture a vaccine for the Coronavirus pandemic.


Today, in the United States, there are government controls that guide and define vaccines’ development and deployment. The Centers for Disease Control and Prevention (CDC) has defined the multiple stages of vaccine development. In their clinical development stage, there are three trial phases.

  • Phase I involves small groups of people (20-80) who receive the trial vaccine and are closely monitored for the immune response’s type and extent. Both the candidate vaccine and placebo are “openly” deployed.
  • Phase II expands the population to people who have characteristics such as age and physical health similar to those for whom the new vaccine is intended, i.e., groups at risk. This phase tests the vaccine’s safety, immunogenicity, proposed doses, immunizations schedule, and delivery method. The candidate vaccine and placebo are deployed in a “double-blind” manner: the subjects don’t know which they are receiving.
  • Phase III involves 10s to 100s of thousands of people (typically 30,000) who test the vaccine for efficacy and safety, studying control groups with placebos, and any adverse effects or rare side effects of the vaccine. Typically, a minimum of 40 days after the booster (second) shot is required for testing efficacy and side effects. There may also be a period of peer reviews of the study.

After a successful Phase III trial, the vaccine developer will submit a New Drug Application to the FDA.

Vaccines for COVID-19

The U.S. Food and Drug Administration (FDA) is responsible for regulating vaccines in the US, including manufacturing and quality control tests for release. This includes the vaccine’s safety and ability to elicit a protective immune response in animal testing, in addition to proposed clinical protocols for studies in humans. Earlier this year, the FDA issued guidance, adding 60 days of testing safety data for Coronavirus trials, before approval. That is yet to be determined. Why?

COVID Vaccine

When will we have a COVID-19 vaccine?

Until today, there are no vaccines that met the requirements described above. There are over 100 studies currently underway. Biotech candidate trials up to now in America have not yet been successful.

However, biotech companies Pfizer and Moderna, based on partnership with German biotech firm BioNTech, have announced promising vaccine candidates with greater than 90% effectiveness, but neither completed Phase III testing nor undergone peer reviews.

Either company may file with the FDA for an Emergency Use Authorization (EUA), which short-circuits the usual strict requirements for vaccine trials and lowers the bar for approval. Today Pfizer and BioNTech announced their intention to do that. Soon others will do the same. Even after FDA approval, there are manufacturing, distribution, and deployment phases.

So far in the US, there have been over 12 million cases and over a quarter of a million reported deaths. But there is hope, as I describe in my next article.


Bill Petro, your friendly neighborhood historian

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About billpetro

Bill Petro writes articles on history, technology, pop culture, and travel. He has been a technology sales enablement executive with extensive experience in Cloud Computing, Automation, Data Center, Information Storage, Big Data/Analytics, Mobile, and Social technologies.

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